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br rs genotype distribution was tested for HardyeWeinberg
2019-10-07
rs145204276 genotype distribution was tested for HardyeWeinberg equilibrium (HWE) using the Pearson c2 test. Differences of rs145204276 genotype frequencies between cases and controls were assessed using the c2 test. Results are presented as odds ratios (ORs) with 95% confidence intervals (CIs) an
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br Declaration of Competing Interest br No potential conflic
2019-10-07
Declaration of Competing Interest No potential conflicts of interest were disclosed. Acknowledgement The authors thank Professor Weijie Zhao at School of Pharmaceutical Science and Technology, Dalian University of Technology, for kindly providing L-02 cell line. Funding We gratefull
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br Clinical variables gene expression profiles and
2019-10-02
Clinical variables, gene expression profiles, and histological pa-rameters have indicated strong biological interactions to BC prog-nosis during recent years (Kourou et al., 2015). Each of the at-tributes can vary by time, and the predictive modeling has to take into account the incremental change
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br Dental maturity evaluation br To
2019-09-24
Dental maturity evaluation To evaluate the DM, the Demirjian method 14 was used, where the final values established by the author of this Okadaic acid method were converted into dental age (DAG). In order to compare the DAG with the chronological age (CAG), a mathematical formula of reason was
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Fig Illustration of the centroids
2019-09-23
Fig. 9. Illustration of the centroids extracted by FCM and BPCM. Table 5 Average and optimal performance of basic classifiers on data subsets. (Average/Optimal) Mean FCM BPCM unlikely to be infected by Ko 143 and vice versa. However, such patterns are not observed in the centroids
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br Fig Summary of MDR
2019-09-23
Fig. 11. Summary of MDR reversal profile of different derivatives of 5-oxo-hexahydroquinoline scaffold. S. Ranjbar et al. agents, also leads to a higher collateral sensitivity, as described for flavonoid compounds (Lorendeau et al., 2014), D series compounds are good leads in order to develo
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br Flow cytometric detection of calcein AM accumulation in
2019-09-21
2.7.2. Flow cytometric detection of calcein-AM accumulation in MRP1-overexpressing Flp-In HEK293 Control and MRP1-expressing Flp-In™-293 Gilteritinib were seeded into 96-well microplates. After an overnight incubation, the medium was changed, and cells were incubated for 30 min with the compounds
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br Fig While the C B cells formed spheroids in
2019-09-16
(Fig. 4). While the C4-2B cells formed spheroids in CA scaffolds, the lower E-cadherin expression compared to 2D cultures indicates that another mechanism may be promoting spheroid formation. PC-3 cells vary their E-cadherin expression in suspension cultures compared with adherent cultures, with
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br Porosity analysis br Sca
2019-09-16
2.5. Porosity analysis Scaffold porosity was measured using a modified liquid displace-ment method where isopropanol was used as the displacement liquid [10]. Rectangular samples (10 mm × 10 mm × 5 mm, n = 5) for each scaffold composition were prepared, the sample dimensions were measured using a
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br In brief we first
2019-09-16
In brief, we first applied data from half of the METABRIC cohort advantages over Integrative Cluster, which was originally proposed by (training set, n = 952) to a machine learning algorithm known as a ran- the provider of the METABRIC data set [19]. The stratification based on dom forest
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Few studies have compared the efficacy among various
2019-09-03
Few studies have compared the efficacy among various dose fractionations. One study comparing 10 Gy x 5 and 20 Gy x 3 in Stage I NSCLC found no significant differences in 1-year local control, distant metastasis, or overall survival [8]. Mild late chest wall toxicity was more common in the group tre
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Moreover it is still uncertain if
2019-09-02
Moreover, it is still uncertain if the levels of in circulating tumor DNA (ctDNA) at osimertinib baseline and during treatment could predict the pattern of resistance. Oxnard et al. observed that patients who lost T790M had only a slightly lower relative T790M AF before osimertinib than patients wh
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The uncertainty involved in our conversion factor
2019-08-26
The uncertainty involved in our conversion factor for past-year exposure to ever exposure is a limitation. Past year exposure is likely to be highly variable and susceptible to many different factors – rendering the conversion to ever exposure extremely difficult. A limited evaluation of the validit
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br Declaration of interests br Author contribution statement
2019-08-16
Declaration of interests Author contribution statement Acknowledgements Introduction Cervical cancer has been previously estimated to be the fourth most common cancer and the fourth most common cause of cancer death for women worldwide in 2012, with an estimated 528,000 new cases and 266
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The study has several strengths as well
2019-08-16
The study has several strengths as well. First, SEER and TCR data are highly valuable sources of patient information, tumor variables and survivorship. Both SEER and TCR met the national Centers for Disease Control (CDC) "high quality" data standards and received Gold certification (highest level) f